{"help":"Return the metadata of a dataset (package) and its resources. :param id: the id or name of the dataset :type id: string","success":true,"result":[{"id":"075a36b9-25af-400e-8b66-32d6234b763e","name":"fecal-microbiota-transplantation-confers-beneficial-metabolic-effects-diet-and-exercise-diet","title":"Fecal microbiota transplantation confers beneficial metabolic effects of diet and exercise on diet-induced obese mice","maintainer":"\u53f0\u7063\u4eba\u9ad4\u5fae\u751f\u7269\u76f8\u8cc7\u6599\u5eab","maintainer_email":"summerhill001@gmail.com","notes":"\u003Cp\u003EPRJNA379878,\u003Cbr \/\u003E\nDiet and exercise are conventional methods for controlling body weight and are linked to alterations in gut microbiota. However, the associations of diet, exercise, and gut microbiota in the control of obesity remain largely unknown. In the present study, using 16S rRNA amplicon sequencing and fecal microbiota transplantation (FMT), normal fat diet (NFD), exercise and their combination resulted in improved metabolic profiles in comparison to sedentary lifestyle with high fat diet (HFD). Moreover, diet exerted more influence than exercise in shaping the gut microbiota. HFD-fed mice receiving FMT from NFD-exercised donors not only showed remarkably reduced food efficacy, but also mitigated metabolic profiles (p \u0026lt; 0.05). The transmissible beneficial effects of FMT were associated with bacterial genera Helicobacter, Odoribacter and AF12 and overrepresentation of oxidative phosphorylation and glycolysis genes. Our findings demonstrate that the beneficial effects of diet and exercise are transmissible via FMT, suggesting a potential therapeutic treatment for obesity.\u003C\/p\u003E\n\u003Cp\u003ESequence files and metadata of all samples have been deposited in National Center for Biotechnology Information Sequence Read Archive under accession number SRP102269, affiliated with BioProject PRJNA379878. The metadata, OTU and taxonomy tables, and COGs and annotation tables (predicted by PICRUSt) have also been deposited in Figshare (\u003Ca href=\u0022https:\/\/doi.org\/10.6084\/m9.figshare.5513548\u0022\u003Ehttps:\/\/doi.org\/10.6084\/m9.figshare.5513548\u003C\/a\u003E), and serve as input data for the R code in Supplementary dataset used to perform all statistical analyses in this manuscript.\u003C\/p\u003E\n","url":"https:\/\/www.hmp.org.tw\/?q=dataset\/fecal-microbiota-transplantation-confers-beneficial-metabolic-effects-diet-and-exercise-diet","state":"Active","private":true,"revision_timestamp":"Thu, 10\/29\/2020 - 10:57","metadata_created":"Thu, 10\/29\/2020 - 02:13","metadata_modified":"Thu, 10\/29\/2020 - 10:57","creator_user_id":"82398fd6-ac0a-446a-a9c0-ab9d797f47f0","type":"Dataset","resources":[{"id":"62d3bc15-2cc9-4a4f-8f9e-7038626f15ec","revision_id":"","url":"https:\/\/www.hmp.org.tw\/sites\/default\/files\/PRJNA379878_Demultiplexed_sequence_counts_summary%20%281%29.pdf","description":"\u003Cp\u003Esequence counts summary\u003C\/p\u003E\n","format":"pdf","state":"Active","revision_timestamp":"Thu, 10\/29\/2020 - 10:53","name":"PRJNA379878_summary","mimetype":"application\/pdf","size":"101.11 KB","created":"Thu, 10\/29\/2020 - 10:53","resource_group_id":"7a5dddf3-4503-464e-865c-c44ccd9cd1e7","last_modified":"Date changed  Thu, 10\/29\/2020 - 10:53"},{"id":"c461ceea-fa8c-4709-8309-3a9a526675ed","revision_id":"","url":"https:\/\/www.hmp.org.tw\/sites\/default\/files\/PRJNA379878_Demultiplexed_sequence_counts_summary_plot%20%281%29.pdf","description":"\u003Cp\u003Essequence counts summary plot\u003C\/p\u003E\n","format":"pdf","state":"Active","revision_timestamp":"Thu, 10\/29\/2020 - 10:53","name":"PRJNA379878_summary_plot","mimetype":"application\/pdf","size":"132.78 KB","created":"Thu, 10\/29\/2020 - 10:53","resource_group_id":"7a5dddf3-4503-464e-865c-c44ccd9cd1e7","last_modified":"Date changed  Thu, 10\/29\/2020 - 10:53"},{"id":"f94ba229-5201-4415-a96e-52c4fc60fdde","revision_id":"","url":"https:\/\/www.hmp.org.tw\/sites\/default\/files\/metadata%20%283%29.tsv","description":"\u003Cp\u003EBiosample\u003C\/p\u003E\n","format":"tsv","state":"Active","revision_timestamp":"Thu, 10\/29\/2020 - 10:54","name":"Biosample","mimetype":"text\/tab-separated-values","size":"9.06 KB","created":"Thu, 10\/29\/2020 - 10:54","resource_group_id":"7a5dddf3-4503-464e-865c-c44ccd9cd1e7","last_modified":"Date changed  Thu, 10\/29\/2020 - 10:54"},{"id":"4b079ca6-b990-4a04-88b5-294033728fed","revision_id":"","url":"https:\/\/www.hmp.org.tw\/sites\/default\/files\/PRJNA379878_manifest%20%282%29.csv","description":"\u003Cp\u003EMaps sample identifiers to fastq. gz or fastq absolute filepaths\u003C\/p\u003E\n","format":"csv","state":"Active","revision_timestamp":"Thu, 10\/29\/2020 - 10:55","name":"PRJNA379878_manifest","mimetype":"text\/csv","size":"7.31 KB","created":"Thu, 10\/29\/2020 - 10:55","resource_group_id":"7a5dddf3-4503-464e-865c-c44ccd9cd1e7","last_modified":"Date changed  Thu, 10\/29\/2020 - 10:55"},{"id":"ba824b88-f254-4415-b98a-ee27e1fd61de","revision_id":"","url":"http:\/\/hmpatnhc.s3-cloud.nchc.org.tw\/vghtpe\/paired-end-demux.qza","description":"\u003Cp\u003E.qza is a qiime zipped artifact\u003C\/p\u003E\n","format":"qza","state":"Active","revision_timestamp":"Thu, 10\/29\/2020 - 10:56","name":"PRJNA379878_qza","mimetype":"qza","size":"","created":"Thu, 10\/29\/2020 - 10:56","resource_group_id":"7a5dddf3-4503-464e-865c-c44ccd9cd1e7","last_modified":"Date changed  Thu, 10\/29\/2020 - 10:56"},{"id":"e562b80e-84a0-45c8-a0a8-4b655f4745f6","revision_id":"","url":"http:\/\/hmpatnhc.s3-cloud.nchc.org.tw\/vghtpe\/paired-end-demux.qzv","description":"\u003Cp\u003E.qzv is a qiime zipped visualization\u003C\/p\u003E\n","format":"qzv","state":"Active","revision_timestamp":"Thu, 10\/29\/2020 - 10:57","name":"PRJNA379878_qzv","mimetype":"qzv","size":"","created":"Thu, 10\/29\/2020 - 10:57","resource_group_id":"7a5dddf3-4503-464e-865c-c44ccd9cd1e7","last_modified":"Date changed  Thu, 10\/29\/2020 - 10:57"}],"tags":[{"id":"716deb55-a0d4-4215-a81f-24f2951dc0ec","vocabulary_id":"2","name":"mouse gut metagenome"}],"groups":[{"description":"\u003Cp\u003E\u4ee5\u553e\u6db2\u3001\u7cde\u4fbf\u3001\u53ca\u764c\u75c7\u7d44\u7e54\u4e4b\u5fae\u83cc\u53e2\u76f8\u4f5c\u70ba\u8a3a\u65b7\u80f0\u81df\u764c\u3001\u9810\u6e2c\u6574\u9ad4\u5b58\u6d3b\u7387\u3001\u53ca\u8abf\u63a7\u6cbb\u7642\u53cd\u61c9\u4e4b\u816b\u7624\u751f\u7269\u6a19\u8a18\u003C\/p\u003E\n","id":"7a5dddf3-4503-464e-865c-c44ccd9cd1e7","image_display_url":"https:\/\/www.hmp.org.tw\/sites\/default\/files\/cmu.jpg","title":"(11) \u4e2d\u570b\u91ab\u85e5\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u6d88\u5316\u91ab\u5b78\u4e2d\u5fc3 - \u6797\u8087\u5802\u91ab\u5e2b\u5718\u968a","name":"group\/11-\u4e2d\u570b\u91ab\u85e5\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u6d88\u5316\u91ab\u5b78\u4e2d\u5fc3-\u6797\u8087\u5802\u91ab\u5e2b\u5718\u968a"}]}]}